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The filtrates are reduced to dryness under vacuo and the residue is treated with a dilute solution of trifluroroacetic acid in acetonitrile to adjust the pH to approximately 2.

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CBT, which is of similar efficacy to ADM [ 9], metformin 1000 mg weight loss pcos several advantages: 1) it reflects the desire of many service users for non-pharmacological treatment; 2) it has no physical side-effects; and 3) it modifies the illness trajectory in that benefits continue after the end of treatment thereby reducing rates of recurrence [ 10].

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